This project aims to understand the molecular networks in the human body. We will develop mathematical models to conduct computational simulations and validate them using artificial tissues, named tissue organoid. The tissues are reproduced on a chip and their molecular dynamics will be analyzed using highly-sensitive omics technologies. The virtual human will be developed by the iterative development and validation of both mathematical models and organs on a chip. We try to understand the rationality of our body as a large and complicated system. Virtual Human Science will be established multidisciplinary research activities.